Isolation and partial characterization of the Streptococcus mutans type AII lantibiotic mutacin K8
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چکیده
منابع مشابه
Isolation and biochemical characterization of a novel lantibiotic mutacin from Streptococcus mutans.
Certain members of the indigenous biota of humans produce antimicrobial substances called bacteriocins, which inhibit other bacteria, including members of their own species. One of these substances, mutacin, is made by Streptococcus mutans, a member of the oral biota. Mutacin inhibits other mutans streptococci as well as many gram-positive exogenous pathogens. Here, we report for the first time...
متن کاملMutacin II, a Bactericidal Lantibiotic from Streptococcus mutans
MICHAEL L. CHIKINDAS,† JAN NOVÁK, ARNOLD J. M. DRIESSEN,* WIL N. KONINGS, KURT M. SCHILLING,‡ AND PAGE W. CAUFIELD Unilever Dental Research, Bebington L63 3JW, United Kingdom; Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294; and Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of G...
متن کاملBiosynthesis and transport of the lantibiotic mutacin 1140 produced by Streptococcus mutans.
UNLABELLED Lantibiotics are ribosomally synthesized peptide antibiotics composed of an N-terminal leader peptide that is cleaved to yield the active antibacterial peptide. Significant advancements in molecular tools that promote the study of lantibiotic biosynthesis can be used in Streptococcus mutans. Herein, we further our understanding of leader peptide sequence and core peptide structural r...
متن کاملGenetic and biochemical analysis of mutacin 1140, a lantibiotic from Streptococcus mutans.
Streptococcus mutans JH1000 and its derivatives were previously shown (J. D. Hillman, K. P. Johnson, and B. I. Yaphe, Infect. Immun. 44:141-144, 1984) to produce a low-molecular-weight, broad-spectrum bacteriocin-like inhibitory substance (BLIS). The thermosensitive vector pTV1-OK harboring Tn917 was used to isolate a BLIS-deficient mutant, DM25, and the mutated gene was recovered by shotgun cl...
متن کامل[Isolation and characterization of Streptococcus mutans].
s), vol. 2. Information Retrieval. Inc.. Washington, D.C. 23. Pollock, J. J., L. I. Katona, H. Goodman, M. I. Cho, and V. J. Iacono. 1981. Bacteriolysis of Streptococcus IoluttlIos BHT by lysozyme and inorganic anions normally present in human saliva. Arch. Oral Biol. 26:711-716. 24. Reider, J. L., and F. L. Macrina. 1977. Plasmid DNA isolation in Streptococcuts ot1iut(utns: glycine-enhanced ce...
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ژورنال
عنوان ژورنال: Microbiology
سال: 2007
ISSN: 1350-0872,1465-2080
DOI: 10.1099/mic.0.2006/003756-0